Anti-SARS1 Polyclonal Antibody (HA659014)

Name: Anti-SARS1 Polyclonal Antibody
Brand: abinScience
SKU: HA659014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HA659014

Descripción

Anti-SARS1 Polyclonal Antibody (HA659014) is a rabbit polyclonal antibody detecting cytoplasmic; 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase; SARS1; SARS; SERS in ELISA, IHC, WB. Suitable for Human, Bovine, Rabbit, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human SARS1 (Ser142-Lys472).

Objetivo

Serine--tRNA ligase, cytoplasmic; 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase; SARS1; SARS; SERS

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P49591, Q9GMB8, P13642, P26638, Q6P799, Q6DRC0

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Serine--tRNA ligase, cytoplasmic (SARS1) is a ~58 kDa protein. Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.

1. Xu, X. et al. (2012) Nature communications 3, 681. PMID: 22353712

2. Xu, X. et al. (2013) Structure (London, England : 1993) 21, 2078-86. PMID: 24095058

3. Wang, C. et al. (2015) Nucleic acids research 43, 10534-45. PMID: 26433229

4. Musante, L. et al. (2017) Human mutation 38, 621-636. PMID: 28236339

5. Ravel, JM. et al. (2021) Human mutation 42, 1576-1583. PMID: 34570399

6. Verdura, E. et al. (2022) Journal of medical genetics 59, 1227-1233. PMID: 36041817

7. Vincent, C. et al. (1997) European journal of biochemistry 250, 77-84. PMID: 9431993

8. Shi, Y. et al. (2014) eLife 3, e02349. PMID: 24940000

9. Herzog, W. et al. (2009) Circulation research 104, 1260-6. PMID: 19423847

10. Fukui, H. et al. (2009) Circulation research 104, 1253-9. PMID: 19423848

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-SARS1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-SARS1 Polyclonal Antibody (HA659014)

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Datasheet

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