Anti-SARS1 Polyclonal Antibody (HA659014)

Name: Anti-SARS1 Polyclonal Antibody
Brand: abinScience
SKU: HA659014
Price: 168 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) : --

Spécification :

50ug
100ug

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HA659014

Description

Anti-SARS1 Polyclonal Antibody (HA659014) is a rabbit polyclonal antibody detecting cytoplasmic; 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase; SARS1; SARS; SERS in ELISA, IHC, WB. Suitable for Human, Bovine, Rabbit, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human SARS1 (Ser142-Lys472).

Cible

Serine--tRNA ligase, cytoplasmic; 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase; SARS1; SARS; SERS

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

P49591, Q9GMB8, P13642, P26638, Q6P799, Q6DRC0

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Serine--tRNA ligase, cytoplasmic (SARS1) is a ~58 kDa protein. Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.

1. Xu, X. et al. (2012) Nature communications 3, 681. PMID: 22353712

2. Xu, X. et al. (2013) Structure (London, England : 1993) 21, 2078-86. PMID: 24095058

3. Wang, C. et al. (2015) Nucleic acids research 43, 10534-45. PMID: 26433229

4. Musante, L. et al. (2017) Human mutation 38, 621-636. PMID: 28236339

5. Ravel, JM. et al. (2021) Human mutation 42, 1576-1583. PMID: 34570399

6. Verdura, E. et al. (2022) Journal of medical genetics 59, 1227-1233. PMID: 36041817

7. Vincent, C. et al. (1997) European journal of biochemistry 250, 77-84. PMID: 9431993

8. Shi, Y. et al. (2014) eLife 3, e02349. PMID: 24940000

9. Herzog, W. et al. (2009) Circulation research 104, 1260-6. PMID: 19423847

10. Fukui, H. et al. (2009) Circulation research 104, 1253-9. PMID: 19423848

Note

For research use only

Images

Reférences

Fiche technique

Anti-SARS1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-SARS1 Polyclonal Antibody (HA659014)

Aperçu

Images

Reférences

Fiche technique

SDS