Anti-SARS1 Polyclonal Antibody (HA659014)

Name: Anti-SARS1 Polyclonal Antibody
Brand: abinScience
SKU: HA659014
Price: 168 USD
Availability: InStock

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Каталожный номер

HA659014

Описание

Anti-SARS1 Polyclonal Antibody (HA659014) is a rabbit polyclonal antibody detecting cytoplasmic; 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase; SARS1; SARS; SERS in ELISA, IHC, WB. Suitable for Human, Bovine, Rabbit, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant human SARS1 (Ser142-Lys472).

Цель

Serine--tRNA ligase, cytoplasmic; 6.1.1.11; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase; SARS1; SARS; SERS

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

P49591, Q9GMB8, P13642, P26638, Q6P799, Q6DRC0

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Serine--tRNA ligase, cytoplasmic (SARS1) is a ~58 kDa protein. Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.

1. Xu, X. et al. (2012) Nature communications 3, 681. PMID: 22353712

2. Xu, X. et al. (2013) Structure (London, England : 1993) 21, 2078-86. PMID: 24095058

3. Wang, C. et al. (2015) Nucleic acids research 43, 10534-45. PMID: 26433229

4. Musante, L. et al. (2017) Human mutation 38, 621-636. PMID: 28236339

5. Ravel, JM. et al. (2021) Human mutation 42, 1576-1583. PMID: 34570399

6. Verdura, E. et al. (2022) Journal of medical genetics 59, 1227-1233. PMID: 36041817

7. Vincent, C. et al. (1997) European journal of biochemistry 250, 77-84. PMID: 9431993

8. Shi, Y. et al. (2014) eLife 3, e02349. PMID: 24940000

9. Herzog, W. et al. (2009) Circulation research 104, 1260-6. PMID: 19423847

10. Fukui, H. et al. (2009) Circulation research 104, 1253-9. PMID: 19423848

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-SARS1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-SARS1 Polyclonal Antibody (HA659014)

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