Anti-SCNN1A Polyclonal Antibody (HW302014)

Name: Anti-SCNN1A Polyclonal Antibody
Brand: abinScience
SKU: HW302014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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SDS

Aperçu

Numéro de catalogue

HW302014

Description

Anti-SCNN1A Polyclonal Antibody (HW302014) is a rabbit polyclonal antibody detecting SCNN1A/SCNN1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SCNN1A (Tyr112-Thr543).

Cible

ENaCA, SCNN1A, Epithelial Na(+) channel subunit alpha, SCNEA, SCNN1, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, Alpha-ENaC

Purification

Purified by antigen affinity column.

Numéro d'accès

P37088

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Epithelial sodium channel subunit alpha (SCNN1A/SCNN1) is a ~75 kDa protein. This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.

1. Noreng, S. et al. (2018) eLife 7. PMID: 30251954

2. Noreng, S. et al. (2020) eLife 9. PMID: 32729833

3. McDonald, FJ. et al. (1994) The American journal of physiology 266, L728-34. PMID: 8023962

4. Voilley, N. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 247-51. PMID: 8278374

5. Goulet, CC. et al. (1998) The Journal of biological chemistry 273, 30012-7. PMID: 9792722

6. Hobbs, CA. et al. (2013) American journal of physiology. Lung cellular and molecular physiology 305, L990-L1001. PMID: 24124190

7. Salih, M. et al. (2017) Journal of the American Society of Nephrology : JASN 28, 3291-3299. PMID: 28710092

8. Saxena, A. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3344-50. PMID: 12107247

Note

For research use only.

Images

Reférences

Fiche technique

Anti-SCNN1A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-SCNN1A Polyclonal Antibody (HW302014)

Aperçu

Images

Reférences

Fiche technique

SDS