Anti-SDCBP Polyclonal Antibody (HT180014)

Name: Anti-SDCBP Polyclonal Antibody
Brand: abinScience
SKU: HT180014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HT180014

Description

Anti-SDCBP Polyclonal Antibody (HT180014) is a rabbit polyclonal antibody detecting SDCBP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SDCBP (Ser2-Val298).

Cible

Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Melanoma differentiation-associated protein 9, SYCL, SDCBP, MDA9, MDA-9, Syntenin-1, Syndecan-binding protein 1, TACIP18, Scaffold protein Pbp1

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

O00560

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Syntenin-1 (SDCBP) is a ~32 kDa protein. Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types.

1. Philley, JV. et al. (2016) Journal of cellular physiology 231, 545-50. PMID: 26291527

2. Hwangbo, C. et al. (2016) Oncogene 35, 389-401. PMID: 25893292

3. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413

4. Kashyap, R. et al. (2015) Frontiers in pharmacology 6, 241. PMID: 26539120

5. Geijsen, N. et al. (2001) Science (New York, N.Y.) 293, 1136-8. PMID: 11498591

6. Zimmermann, P. et al. (2001) Molecular biology of the cell 12, 339-50. PMID: 11179419

7. Fernández-Larrea, J. et al. (1999) Molecular cell 3, 423-33. PMID: 10230395

Note

For research use only.

Images

Reférences

Fiche technique

Anti-SDCBP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-SDCBP Polyclonal Antibody (HT180014)

Aperçu

Images

Reférences

Fiche technique

SDS