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| カタログ番号 | HT180014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SDCBP Polyclonal Antibody (HT180014) is a rabbit polyclonal antibody detecting SDCBP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SDCBP (Ser2-Val298). | ||||||||
| ターゲット | Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Melanoma differentiation-associated protein 9, SYCL, SDCBP, MDA9, MDA-9, Syntenin-1, Syndecan-binding protein 1, TACIP18, Scaffold protein Pbp1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00560 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Syntenin-1 (SDCBP) is a ~32 kDa protein. Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. 1. Philley, JV. et al. (2016) Journal of cellular physiology 231, 545-50. PMID: 26291527 2. Hwangbo, C. et al. (2016) Oncogene 35, 389-401. PMID: 25893292 3. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413 4. Kashyap, R. et al. (2015) Frontiers in pharmacology 6, 241. PMID: 26539120 5. Geijsen, N. et al. (2001) Science (New York, N.Y.) 293, 1136-8. PMID: 11498591 6. Zimmermann, P. et al. (2001) Molecular biology of the cell 12, 339-50. PMID: 11179419 7. Fernández-Larrea, J. et al. (1999) Molecular cell 3, 423-33. PMID: 10230395 | ||||||||
| 注意事項 | For research use only. |
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