Anti-SDCBP Polyclonal Antibody (HT180014)

Name: Anti-SDCBP Polyclonal Antibody
Brand: abinScience
SKU: HT180014
Price: 168 USD
Availability: InStock

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Каталожный номер

HT180014

Описание

Anti-SDCBP Polyclonal Antibody (HT180014) is a rabbit polyclonal antibody detecting SDCBP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human SDCBP (Ser2-Val298).

Цель

Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Melanoma differentiation-associated protein 9, SYCL, SDCBP, MDA9, MDA-9, Syntenin-1, Syndecan-binding protein 1, TACIP18, Scaffold protein Pbp1

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

O00560

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Syntenin-1 (SDCBP) is a ~32 kDa protein. Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types.

1. Philley, JV. et al. (2016) Journal of cellular physiology 231, 545-50. PMID: 26291527

2. Hwangbo, C. et al. (2016) Oncogene 35, 389-401. PMID: 25893292

3. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413

4. Kashyap, R. et al. (2015) Frontiers in pharmacology 6, 241. PMID: 26539120

5. Geijsen, N. et al. (2001) Science (New York, N.Y.) 293, 1136-8. PMID: 11498591

6. Zimmermann, P. et al. (2001) Molecular biology of the cell 12, 339-50. PMID: 11179419

7. Fernández-Larrea, J. et al. (1999) Molecular cell 3, 423-33. PMID: 10230395

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-SDCBP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-SDCBP Polyclonal Antibody (HT180014)

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