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| カタログ番号 | HB906014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SERPINB1 Polyclonal Antibody (HB906014) is a rabbit polyclonal antibody detecting SERPINB1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SERPINB1 (Leu13-Leu252). | ||||||||
| ターゲット | ELANH2, Peptidase inhibitor 2, Serpin B1, SERPINB1, MNEI, M/NEI, EI, LEI, PI2, Monocyte/neutrophil elastase inhibitor, PI-2, Leukocyte elastase inhibitor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P30740 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Leukocyte elastase inhibitor (SERPINB1) is a ~42 kDa protein. Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. 1. Choi, YJ. et al. (2019) Nature immunology 20, 276-287. PMID: 30692621 2. Cooley, J. et al. (2001) Biochemistry 40, 15762-70. PMID: 11747453 3. Wang, L. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1319-30. PMID: 23269243 4. El Ouaamari, A. et al. (2016) Cell metabolism 23, 194-205. PMID: 26701651 | ||||||||
| 注意事項 | For research use only. |
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