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| カタログ番号 | HB387014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SF3A3 Polyclonal Antibody (HB387014) is a rabbit polyclonal antibody detecting Splicing factor 3A subunit 3; SF3a60; Spliceosome-associated protein 61; SAP 61; SF3A3; SAP61 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human SF3A3 (Met1-Leu501). | ||||||||
| ターゲット | Splicing factor 3A subunit 3; SF3a60; Spliceosome-associated protein 61; SAP 61; SF3A3; SAP61 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q12874, Q9D554 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Splicing factor 3A subunit 3 (SF3A3) is a ~58 kDa protein. Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. 1. Das, R. et al. (2000) Molecular cell 5, 779-87. PMID: 10882114 2. Nesic, D. et al. (2001) Molecular and cellular biology 21, 6406-17. PMID: 11533230 3. Zhang, Z. et al. (2020) Nature 583, 310-313. PMID: 32494006 4. Tholen, J. et al. (2022) Science (New York, N.Y.) 375, 50-57. PMID: 34822310 5. Chiara, MD. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 6403-7. PMID: 8022796 6. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106 7. Zhan, X. et al. (2018) Cell research 28, 1129-1140. PMID: 30315277 | ||||||||
| 注意事項 | For research use only |
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