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| カタログ番号 | HV692014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SIRT1 Polyclonal Antibody (HV692014) is a rabbit polyclonal antibody detecting SIRT1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SIRT1 (Ile194-Ser747). | ||||||||
| ターゲット | NAD-dependent protein deacylase sirtuin-1, hSIR2, NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, 75SirT1, SIR2L1, Regulatory protein SIR2 homolog 1, SIRT1, hSIRT1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96EB6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) is a ~81 kDa protein. NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT). 1. Vaziri, H. et al. (2001) Cell 107, 149-59. PMID: 11672523 2. Langley, E. et al. (2002) The EMBO journal 21, 2383-96. PMID: 12006491 3. Brunet, A. et al. (2004) Science (New York, N.Y.) 303, 2011-5. PMID: 14976264 4. Motta, MC. et al. (2004) Cell 116, 551-63. PMID: 14980222 5. van der Horst, A. et al. (2004) The Journal of biological chemistry 279, 28873-9. PMID: 15126506 6. Yeung, F. et al. (2004) The EMBO journal 23, 2369-80. PMID: 15152190 7. Cohen, HY. et al. (2004) Science (New York, N.Y.) 305, 390-2. PMID: 15205477 8. Vaquero, A. et al. (2004) Molecular cell 16, 93-105. PMID: 15469825 9. Yang, Y. et al. (2005) The EMBO journal 24, 1021-32. PMID: 15692560 10. Michishita, E. et al. (2005) Molecular biology of the cell 16, 4623-35. PMID: 16079181 | ||||||||
| 注意事項 | For research use only. |
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