

| Numéro de catalogue | VK100014 | ||||
|---|---|---|---|---|---|
| Description |
Anti-SIV VPX Polyclonal Antibody (VK100014) is a rabbit polyclonal antibody detecting vpx protein in ELISA, IHC, WB.
Highlights
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| Reactivité des espèces | Simian immunodeficiency virus (SIV) | ||||
| Applications | ELISA, IHC, WB | ||||
| Espèce hôte | Rabbit | ||||
| Clonalité | Polyclonal | ||||
| Isotype | IgG | ||||
| Immunogène | E. coli - derived recombinant SIV VPX (Asp26-Cys90). | ||||
| Cible | vpx protein, vpx | ||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||
| Purification | Purified by antigen affinity column. | ||||
| Numéro d'accès | Q02842 | ||||
| Forme | Liquid | ||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Contexte | Protein Vpx is a ~14 kDa protein. Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host DCAF1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. | ||||
| Note | For research use only. |
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