中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | VK100014 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-SIV VPX Polyclonal Antibody (VK100014) is a rabbit polyclonal antibody detecting vpx protein in ELISA, IHC, WB.
Highlights
|
||||
| 種反応性 | Simian immunodeficiency virus (SIV) | ||||
| アプリケーション | ELISA, IHC, WB | ||||
| 宿主種 | Rabbit | ||||
| クローン性 | Polyclonal | ||||
| アイソタイプ | IgG | ||||
| 免疫原 | E. coli - derived recombinant SIV VPX (Asp26-Cys90). | ||||
| ターゲット | vpx protein, vpx | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 精製 | Purified by antigen affinity column. | ||||
| アクセッション番号 | Q02842 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||
| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Protein Vpx is a ~14 kDa protein. Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host DCAF1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. | ||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
