Anti-SKP2 Polyclonal Antibody (HC635014)

Name: Anti-SKP2 Polyclonal Antibody
Brand: abinScience
SKU: HC635014
Price: 168 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD): --

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC635014

Descripción

Anti-SKP2 Polyclonal Antibody (HC635014) is a rabbit polyclonal antibody detecting SKP2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SKP2 (Lys43-Leu354).

Objetivo

Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, SKP2, p45skp2, FBXL1, F-box protein Skp2

Purificación

Purified by antigen affinity column.

Número de acceso

Q13309

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

S-phase kinase-associated protein 2 (SKP2) is a ~47 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1.

1. Yu, ZK. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 11324-9. PMID: 9736735

2. Méndez, J. et al. (2002) Molecular cell 9, 481-91. PMID: 11931757

3. Tedesco, D. et al. (2002) Genes & development 16, 2946-57. PMID: 12435635

4. von der Lehr, N. et al. (2003) Molecular cell 11, 1189-200. PMID: 12769844

5. Li, X. et al. (2003) The Journal of biological chemistry 278, 30854-8. PMID: 12840033

6. Tokarz, S. et al. (2004) The Journal of biological chemistry 279, 46424-30. PMID: 15342634

7. Huang, H. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1649-54. PMID: 15668399

8. Jiang, H. et al. (2005) Molecular cell 18, 699-709. PMID: 15949444

9. Barboric, M. et al. (2005) Journal of virology 79, 11135-41. PMID: 16103164

10. Wang, W. et al. (2005) Biochemistry 44, 14553-64. PMID: 16262255

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-SKP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-SKP2 Polyclonal Antibody (HC635014)

Vista general

Imágenes

Referencias

Datasheet

SDS