中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC635014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SKP2 Polyclonal Antibody (HC635014) is a rabbit polyclonal antibody detecting SKP2 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SKP2 (Lys43-Leu354). | ||||||||
| ターゲット | Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, SKP2, p45skp2, FBXL1, F-box protein Skp2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13309 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | S-phase kinase-associated protein 2 (SKP2) is a ~47 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. 1. Yu, ZK. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 11324-9. PMID: 9736735 2. Méndez, J. et al. (2002) Molecular cell 9, 481-91. PMID: 11931757 3. Tedesco, D. et al. (2002) Genes & development 16, 2946-57. PMID: 12435635 4. von der Lehr, N. et al. (2003) Molecular cell 11, 1189-200. PMID: 12769844 5. Li, X. et al. (2003) The Journal of biological chemistry 278, 30854-8. PMID: 12840033 6. Tokarz, S. et al. (2004) The Journal of biological chemistry 279, 46424-30. PMID: 15342634 7. Huang, H. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1649-54. PMID: 15668399 8. Jiang, H. et al. (2005) Molecular cell 18, 699-709. PMID: 15949444 9. Barboric, M. et al. (2005) Journal of virology 79, 11135-41. PMID: 16103164 10. Wang, W. et al. (2005) Biochemistry 44, 14553-64. PMID: 16262255 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
