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| カタログ番号 | HX864014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC12A3 (Glu3-Cys146). | ||||||||
| ターゲット | TSC, SLC12A3, NCC, Solute carrier family 12 member 3, Na-Cl cotransporter, Thiazide-sensitive sodium-chloride cotransporter, Na-Cl symporter | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P55017 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Solute carrier family 12 member 3 (SLC12A3) is a ~113 kDa protein. Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1. 1. Richardson, C. et al. (2008) Journal of cell science 121, 675-84. PMID: 18270262 2. Cruz-Rangel, S. et al. (2011) American journal of physiology. Cell physiology 301, C601-8. PMID: 21613606 3. Glaudemans, B. et al. (2012) European journal of human genetics : EJHG 20, 263-70. PMID: 22009145 4. Nan, J. et al. (2022) Science advances 8, eadd7176. PMID: 36351028 5. Fan, M. et al. (2023) Nature 614, 788-793. PMID: 36792826 | ||||||||
| 注意事項 | For research use only. |
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