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| カタログ番号 | HW317014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SLC19A1 Polyclonal Antibody (HW317014) is a rabbit polyclonal antibody detecting SLC19A1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC19A1 (Leu455-Gln591). | ||||||||
| ターゲット | Intestinal folate carrier 1, FOLT, Solute carrier family 19 member 1, RFC1, hSLC19A1, IFC-1, SLC19A1, RFT-1, FLOT1, RFC, Placental folate transporter, Reduced folate transporter 1, Reduced folate transporter, Reduced folate carrier protein, hRFC | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P41440 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Reduced folate transporter (SLC19A1) is a ~64 kDa protein. Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also mediates the import of antifolate drug methotrexate. 1. Chancy, CD. et al. (2000) The Journal of biological chemistry 275, 20676-84. PMID: 10787414 2. Witt, TL. et al. (2004) The Journal of biological chemistry 279, 46755-63. PMID: 15337749 3. Hou, Z. et al. (2005) The Journal of biological chemistry 280, 36206-13. PMID: 16115875 4. Visentin, M. et al. (2012) Molecular pharmacology 82, 209-16. PMID: 22554803 5. Ritchie, C. et al. (2019) Molecular cell 75, 372-381.e5. PMID: 31126740 6. Luteijn, RD. et al. (2019) Nature 573, 434-438. PMID: 31511694 7. Svaton, M. et al. (2020) Blood 135, 2427-2431. PMID: 32276275 8. Wright, NJ. et al. (2022) Nature 609, 1056-1062. PMID: 36071163 9. Zhang, Q. et al. (2022) Nature 612, 170-176. PMID: 36265513 10. Dang, Y. et al. (2022) Cell discovery 8, 141. PMID: 36575193 | ||||||||
| 注意事項 | For research use only. |
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