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| カタログ番号 | HW669014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SLC1A1 Polyclonal Antibody (HW669014) is a rabbit polyclonal antibody detecting SLC1A1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SLC1A1 (Ser115-Gly209). | ||||||||
| ターゲット | EAAC1, EAAT3, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1, Excitatory amino-acid carrier 1, SLC1A1, Excitatory amino acid transporter 3, Neuronal and epithelial glutamate transporter | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43005 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Excitatory amino acid transporter 3 (SLC1A1) is a ~57 kDa protein. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. 1. Bailey, CG. et al. (2011) The Journal of clinical investigation 121, 446-53. PMID: 21123949 2. Abousaab, A. et al. (2016) The Journal of membrane biology 249, 239-49. PMID: 26690923 3. Qiu, B. et al. (2021) Science advances 7. PMID: 33658209 4. Arriza, JL. et al. (1994) The Journal of neuroscience : the official journal of the Society for Neuroscience 14, 5559-69. PMID: 7521911 5. Kanai, Y. et al. (1994) The Journal of biological chemistry 269, 20599-606. PMID: 7914198 6. Zerangue, N. et al. (1996) Nature 383, 634-7. PMID: 8857541 | ||||||||
| 注意事項 | For research use only. |
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