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| カタログ番号 | HA640014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SLC1A4 Polyclonal Antibody (HA640014) is a rabbit polyclonal antibody detecting Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4; SLC1A4; ASCT1; SATT in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human SLC1A4 (Lys140-Thr216). | ||||||||
| ターゲット | Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4; SLC1A4; ASCT1; SATT | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43007, A2VDL4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Neutral amino acid transporter A (SLC1A4) is a ~55 kDa protein. Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. Exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine and L-alanine in a bidirectional way. Involved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. In astrocytes at excitatory synapses, mediates electrogenic D-serine influx coupled to L-serine efflux and L-serine shuttling to neurons for de novo D-serine synthesis. 1. Scopelliti, AJ. et al. (2014) The Journal of biological chemistry 289, 17468-79. PMID: 24808181 2. Foster, AC. et al. (2016) PloS one 11, e0156551. PMID: 27272177 3. Stehantsev, P. et al. (2021) Computational and structural biotechnology journal 19, 5246-5254. PMID: 34630942 4. Zerangue, N. et al. (1996) The Journal of biological chemistry 271, 27991-4. PMID: 8910405 5. Pinilla-Tenas, J. et al. (2003) The Journal of membrane biology 195, 27-32. PMID: 14502423 6. Damseh, N. et al. (2015) Journal of medical genetics 52, 541-7. PMID: 26041762 7. Arriza, JL. et al. (1993) The Journal of biological chemistry 268, 15329-32. PMID: 8101838 8. Shafqat, S. et al. (1993) The Journal of biological chemistry 268, 15351-5. PMID: 8340364 | ||||||||
| 注意事項 | For research use only |
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