Anti-SLCO1B1/LST-1/OATP-2 Polyclonal Antibody (HP744014)

Name: Anti-SLCO1B1/LST-1/OATP-2 Polyclonal Antibody
Brand: abinScience
SKU: HP744014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HP744014

Description

Anti-SLCO1B1/LST-1/OATP-2 Polyclonal Antibody (HP744014) is a rabbit polyclonal antibody detecting SLCO1B1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SLCO1B1/LST-1/OATP-2 (Phe426-Phe537).

Cible

LST1, OATP1B1, OATP2, SLCO1B1, Solute carrier family 21 member 6, OATP-2, Sodium-independent organic anion-transporting polypeptide 2, LST-1, SLC21A6, OATP-C, OATPC, Solute carrier organic anion transporter family member 1B1, Liver-specific organic anion transporter 1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Y6L6

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Solute carrier organic anion transporter family member 1B1 (SLCO1B1/LST-1) is a ~76 kDa protein. Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition.

1. Abe, T. et al. (1999) The Journal of biological chemistry 274, 17159-63. PMID: 10358072

2. Hirano, M. et al. (2004) The Journal of pharmacology and experimental therapeutics 311, 139-46. PMID: 15159445

3. Mahagita, C. et al. (2007) American journal of physiology. Gastrointestinal and liver physiology 293, G271-8. PMID: 17412826

4. Hsiang, B. et al. (1999) The Journal of biological chemistry 274, 37161-8. PMID: 10601278

5. Tamai, I. et al. (2000) Biochemical and biophysical research communications 273, 251-60. PMID: 10873595

6. Kullak-Ublick, GA. et al. (2001) Gastroenterology 120, 525-33. PMID: 11159893

7. Michalski, C. et al. (2002) The Journal of biological chemistry 277, 43058-63. PMID: 12196548

8. Briz, O. et al. (2003) The Biochemical journal 371, 897-905. PMID: 12568656

Note

For research use only.

Images

Reférences

Fiche technique

Anti-SLCO1B1/LST-1/OATP-2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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