| Цель |
LST1, OATP1B1, OATP2, SLCO1B1, Solute carrier family 21 member 6, OATP-2, Sodium-independent organic anion-transporting polypeptide 2, LST-1, SLC21A6, OATP-C, OATPC, Solute carrier organic anion transporter family member 1B1, Liver-specific organic anion transporter 1 |
| Буфер хранения |
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
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| Фон | Solute carrier organic anion transporter family member 1B1 (SLCO1B1/LST-1) is a ~76 kDa protein. Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. 1. Abe, T. et al. (1999) The Journal of biological chemistry 274, 17159-63. PMID: 103580722. Hirano, M. et al. (2004) The Journal of pharmacology and experimental therapeutics 311, 139-46. PMID: 151594453. Mahagita, C. et al. (2007) American journal of physiology. Gastrointestinal and liver physiology 293, G271-8. PMID: 174128264. Hsiang, B. et al. (1999) The Journal of biological chemistry 274, 37161-8. PMID: 106012785. Tamai, I. et al. (2000) Biochemical and biophysical research communications 273, 251-60. PMID: 108735956. Kullak-Ublick, GA. et al. (2001) Gastroenterology 120, 525-33. PMID: 111598937. Michalski, C. et al. (2002) The Journal of biological chemistry 277, 43058-63. PMID: 121965488. Briz, O. et al. (2003) The Biochemical journal 371, 897-905. PMID: 12568656 |
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