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| カタログ番号 | HB267014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SMPD1 Polyclonal Antibody (HB267014) is a rabbit polyclonal antibody detecting SMPD1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SMPD1 (Gly319-Gly579). | ||||||||
| ターゲット | aSMase, SMPD1, Acid sphingomyelinase, Sphingomyelin phosphodiesterase, ASM | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P17405 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sphingomyelin phosphodiesterase (SMPD1) is a ~69 kDa protein. Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form. 1. Grassmé, H. et al. (2003) Nature medicine 9, 322-30. PMID: 12563314 2. Schuchman, EH. et al. (1991) The Journal of biological chemistry 266, 8531-9. PMID: 1840600 3. Jones, I. et al. (2008) Molecular genetics and metabolism 95, 152-62. PMID: 18815062 4. Oninla, VO. et al. (2014) Journal of lipid research 55, 2606-19. PMID: 25339683 5. Acuña, M. et al. (2016) European journal of human genetics : EJHG 24, 208-13. PMID: 25920558 6. Acuña, M. et al. (2016) Biochemical and biophysical research communications 479, 496-501. PMID: 27659707 7. Carpinteiro, A. et al. (2020) Cell reports. Medicine 1, 100142. PMID: 33163980 8. Jenkins, RW. et al. (2010) The Journal of biological chemistry 285, 35706-18. PMID: 20807762 9. Jenkins, RW. et al. (2011) The Journal of biological chemistry 286, 3777-88. PMID: 21098024 10. Schissel, SL. et al. (1998) The Journal of biological chemistry 273, 18250-9. PMID: 9660788 | ||||||||
| 注意事項 | For research use only. |
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