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| カタログ番号 | ZA538043 | ||||
|---|---|---|---|---|---|
| アプリケーション | ELISA | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1 | ||||
| クローンID | C08 | ||||
| ターゲット | Alpha-cobratoxin | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >90% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P01391 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Alpha-cobratoxin is a ~7 kDa protein. Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA). 1. Osipov, AV. et al. (2008) The Journal of biological chemistry 283, 14571-80. PMID: 18381281 2. Osipov, AV. et al. (2012) The Journal of biological chemistry 287, 6725-34. PMID: 22223648 3. Servent, D. et al. (1997) The Journal of biological chemistry 272, 24279-86. PMID: 9305882 4. Kudryavtsev, DS. et al. (2015) The Journal of biological chemistry 290, 22747-58. PMID: 26221036 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Snake Venom Antibody (C08)
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