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| カタログ番号 | HT326014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SOCS2 Polyclonal Antibody (HT326014) is a rabbit polyclonal antibody detecting SOCS2 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Rat, and Pig.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SOCS2 (Met1-Val198). | ||||||||
| ターゲット | CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, STATI2, CIS2, Cytokine-inducible SH2 protein 2, SSI2, Suppressor of cytokine signaling 2, SOCS-2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14508 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Suppressor of cytokine signaling 2 (SOCS2) is a ~22 kDa protein. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. 1. Eyckerman, S. et al. (2001) Nature cell biology 3, 1114-9. PMID: 11781573 2. Vesterlund, M. et al. (2011) PloS one 6, e25358. PMID: 21980433 3. Bulatov, E. et al. (2015) The Journal of biological chemistry 290, 4178-91. PMID: 25505247 4. Kung, WW. et al. (2019) Nature communications 10, 2534. PMID: 31182716 5. Linossi, EM. et al. (2021) Nature communications 12, 7032. PMID: 34857742 6. Ramachandran, S. et al. (2023) Nature communications 14, 6345. PMID: 37816714 | ||||||||
| 注意事項 | For research use only. |
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