

| Каталожный номер | HT326014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-SOCS2 Polyclonal Antibody (HT326014) is a rabbit polyclonal antibody detecting SOCS2 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Rat, and Pig.
Highlights
|
||||||||
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SOCS2 (Met1-Val198). | ||||||||
| Цель | CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, STATI2, CIS2, Cytokine-inducible SH2 protein 2, SSI2, Suppressor of cytokine signaling 2, SOCS-2 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O14508 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Suppressor of cytokine signaling 2 (SOCS2) is a ~22 kDa protein. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. 1. Eyckerman, S. et al. (2001) Nature cell biology 3, 1114-9. PMID: 11781573 2. Vesterlund, M. et al. (2011) PloS one 6, e25358. PMID: 21980433 3. Bulatov, E. et al. (2015) The Journal of biological chemistry 290, 4178-91. PMID: 25505247 4. Kung, WW. et al. (2019) Nature communications 10, 2534. PMID: 31182716 5. Linossi, EM. et al. (2021) Nature communications 12, 7032. PMID: 34857742 6. Ramachandran, S. et al. (2023) Nature communications 14, 6345. PMID: 37816714 | ||||||||
| Примечание | For research use only. |
Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
Быстрый доступ
Свяжитесь с нами
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский