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| カタログ番号 | HX841014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SORD Polyclonal Antibody (HX841014) is a rabbit polyclonal antibody detecting SORD in ELISA, IHC, WB. Suitable for Human, Bovine, Macaca fascicularis, Ovis aries, and Pongo abelii.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SORD (Ala98-Gln355). | ||||||||
| ターゲット | (R, R)-butanediol dehydrogenase, RDH, Polyol dehydrogenase, Sorbitol dehydrogenase, Ribitol dehydrogenase, SORD, Xylitol dehydrogenase, XDH, L-iditol 2-dehydrogenase, SDH | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q00796 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sorbitol dehydrogenase (SORD) is a ~38 kDa protein. Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. 1. Maret, W. et al. (1988) Biochemistry 27, 1622-8. PMID: 3365415 2. Pauly, TA. et al. (2003) Structure (London, England : 1993) 11, 1071-85. PMID: 12962626 3. Safi, SZ. et al. (2014) BioMed research international 2014, 801269. PMID: 25105142 4. Dewanjee, S. et al. (2018) European journal of pharmacology 833, 472-523. PMID: 29966615 5. Frenette, G. et al. (2006) Journal of andrology 27, 233-9. PMID: 16278369 | ||||||||
| 注意事項 | For research use only. |
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