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| カタログ番号 | HW480014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SOX9 Polyclonal Antibody (HW480014) is a rabbit polyclonal antibody detecting SOX9 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Callithrix jacchus, and Dog.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SOX9 (Met1-Lys151). | ||||||||
| ターゲット | Transcription factor SOX-9, SOX9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P48436 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transcription factor SOX-9 (SOX9) is a ~56 kDa protein. Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. 1. Matsushita, M. et al. (2013) American journal of medical genetics. Part A 161A, 2528-34. PMID: 24038782 2. Südbeck, P. et al. (1996) Nature genetics 13, 230-2. PMID: 8640233 | ||||||||
| 注意事項 | For research use only. |
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