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| カタログ番号 | HY593014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SP1 (Leu260-Ala591). | ||||||||
| ターゲット | SP1, TSFP1, Transcription factor Sp1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08047 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transcription factor Sp1 is a ~80 kDa protein. Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. 1. Ding, H. et al. (1999) The Journal of biological chemistry 274, 19573-80. PMID: 10391891 2. Yang, X. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 6611-6. PMID: 11371615 3. Milanini-Mongiat, J. et al. (2002) The Journal of biological chemistry 277, 20631-9. PMID: 11904305 4. Bonello, MR. et al. (2004) The Journal of biological chemistry 279, 2377-82. PMID: 14593115 5. Hsu, MC. et al. (2006) The Journal of biological chemistry 281, 4718-25. PMID: 16377629 6. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 16478997 7. Zhang, Y. et al. (2006) Molecular and cellular biology 26, 6748-61. PMID: 16943418 8. Vicart, A. et al. (2006) Journal of molecular biology 364, 897-908. PMID: 17049555 9. Olofsson, BA. et al. (2007) Molecular cancer research : MCR 5, 1319-30. PMID: 18171990 10. Chuang, JY. et al. (2008) Molecular biology of the cell 19, 1139-51. PMID: 18199680 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SP1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: K562 cell lysate
Lane 3: HepG2 cell lysate
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