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| カタログ番号 | HV674014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SPHK1 Polyclonal Antibody (HV674014) is a rabbit polyclonal antibody detecting SPHK1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SPHK1 (Ser148-Leu384). | ||||||||
| ターゲット | SPHK, SK 1, SPK, Acetyltransferase SPHK1, Sphingosine kinase 1, SPHK1, SPK 1, SK1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NYA1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sphingosine kinase 1 (SPHK1) is a ~42 kDa protein. Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion. 1. Gijsbers, S. et al. (2002) Biochimica et biophysica acta 1580, 1-8. PMID: 11923095 2. Alvarez, SE. et al. (2010) Nature 465, 1084-8. PMID: 20577214 3. Wang, Z. et al. (2013) Structure (London, England : 1993) 21, 798-809. PMID: 23602659 4. Shen, H. et al. (2014) Nature cell biology 16, 652-62. PMID: 24929359 5. Lee, JY. et al. (2018) Nature communications 9, 1479. PMID: 29662056 6. Maceyka, M. et al. (2005) The Journal of biological chemistry 280, 37118-29. PMID: 16118219 7. Adada, MM. et al. (2013) The Journal of biological chemistry 288, 27667-27679. PMID: 23935096 8. Lima, S. et al. (2017) The Journal of biological chemistry 292, 3074-3088. PMID: 28049734 | ||||||||
| 注意事項 | For research use only. |
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