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| カタログ番号 | HV241014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ST6GALNAC6 Polyclonal Antibody (HV241014) is a rabbit polyclonal antibody detecting ST6GALNAC6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ST6GALNAC6 (Val67-Thr333). | ||||||||
| ターゲット | hST6GalNAc VI, SIAT7-F, Sialyltransferase 7F, ST6GalNAcVI, SIAT7F, Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 6, GalNAc alpha-2, 6-sialyltransferase VI, ST6GalNAc VI, ST6GALNAC6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q969X2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6/SIAT7-F) is a ~38 kDa protein. Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside). 1. Tsuchida, A. et al. (2003) The Journal of biological chemistry 278, 22787-94. PMID: 12668675 2. Senda, M. et al. (2007) The Biochemical journal 402, 459-70. PMID: 17123352 | ||||||||
| 注意事項 | For research use only. |
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