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| カタログ番号 | HF596014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-STAMBP Polyclonal Antibody (HF596014) is a rabbit polyclonal antibody detecting STAMBP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human STAMBP (Lys126-Ser368). | ||||||||
| ターゲット | Endosome-associated ubiquitin isopeptidase, STAM-binding protein, AMSH, Associated molecule with the SH3 domain of STAM, STAMBP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95630 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | STAM-binding protein (STAMBP) is a ~48 kDa protein. Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. 1. McCullough, J. et al. (2004) The Journal of cell biology 166, 487-92. PMID: 15314065 2. McDonell, LM. et al. (2013) Nature genetics 45, 556-62. PMID: 23542699 3. Guo, Y. et al. (2021) The Journal of biological chemistry 297, 101107. PMID: 34425109 4. Tanaka, N. et al. (1999) The Journal of biological chemistry 274, 19129-35. PMID: 10383417 5. Itoh, F. et al. (2001) The EMBO journal 20, 4132-42. PMID: 11483516 6. Ma, YM. et al. (2007) The Journal of biological chemistry 282, 9805-9812. PMID: 17261583 | ||||||||
| 注意事項 | For research use only. |
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