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Anti-STAT2 Polyclonal Antibody (HW807014)

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Vista general
Número de catálogoHW807014
Descripción
Anti-STAT2 Polyclonal Antibody (HW807014) is a rabbit polyclonal antibody detecting STAT2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human STAT2 (Glu616-Ser849).
Objetivo p113, STAT2, Signal transducer and activator of transcription 2
Purificación Purified by antigen affinity column.
Número de acceso P52630
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Signal transducer and activator of transcription 2 (STAT2) is a ~97 kDa protein. Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs.

1. Hambleton, S. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3053-8. PMID: 23391734
2. Bluyssen, HA. et al. (1997) The Journal of biological chemistry 272, 4600-5. PMID: 9020188
3. Arimoto, KI. et al. (2017) Nature structural & molecular biology 24, 279-289. PMID: 28165510
4. Shahni, R. et al. (2015) Brain : a journal of neurology 138, 2834-46. PMID: 26122121
Nota For research use only.
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-STAT2 Polyclonal Antibody

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