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| カタログ番号 | HW807014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-STAT2 Polyclonal Antibody (HW807014) is a rabbit polyclonal antibody detecting STAT2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human STAT2 (Glu616-Ser849). | ||||||||
| ターゲット | p113, STAT2, Signal transducer and activator of transcription 2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P52630 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Signal transducer and activator of transcription 2 (STAT2) is a ~97 kDa protein. Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. 1. Hambleton, S. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3053-8. PMID: 23391734 2. Bluyssen, HA. et al. (1997) The Journal of biological chemistry 272, 4600-5. PMID: 9020188 3. Arimoto, KI. et al. (2017) Nature structural & molecular biology 24, 279-289. PMID: 28165510 4. Shahni, R. et al. (2015) Brain : a journal of neurology 138, 2834-46. PMID: 26122121 | ||||||||
| 注意事項 | For research use only. |
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