Anti-STAT3 Polyclonal Antibody (HW708014)

Name: Anti-STAT3 Polyclonal Antibody
Brand: abinScience
SKU: HW708014
Price: 96 USD
Availability: InStock

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Vista general

Número de catálogo

HW708014

Descripción

Anti-STAT3 Polyclonal Antibody (HW708014) is a rabbit polyclonal antibody detecting STAT3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human STAT3 (Met1-Met770).

Objetivo

Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor

Purificación

Purified by antigen affinity column.

Número de acceso

P40763

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

1. Tsai, YT. et al. (2000) Molecular and cellular biology 20, 2043-54. PMID: 10688651

2. Yamamoto, T. et al. (2002) Biochemical and biophysical research communications 297, 811-7. PMID: 12359225

3. Shao, H. et al. (2003) Cancer research 63, 3923-30. PMID: 12873986

4. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 15194700

5. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507

6. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

7. Saxena, NK. et al. (2007) The Journal of biological chemistry 282, 13316-25. PMID: 17344214

8. Jiang, H. et al. (2008) Biochemical and biophysical research communications 368, 1-5. PMID: 18242580

9. Hou, T. et al. (2008) The Journal of biological chemistry 283, 30725-34. PMID: 18782771

10. Gao, X. et al. (2012) Molecular cell 45, 598-609. PMID: 22306293

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-STAT3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: A549 cell lysate
Lane 3: A431 cell lysate
Lane 4: 293T cell lysate