Anti-STAT3 Polyclonal Antibody (HW708014)

Name: Anti-STAT3 Polyclonal Antibody
Brand: abinScience
SKU: HW708014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HW708014

Описание

Anti-STAT3 Polyclonal Antibody (HW708014) is a rabbit polyclonal antibody detecting STAT3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human STAT3 (Met1-Met770).

Цель

Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor

Очистка

Purified by antigen affinity column.

Номер доступа

P40763

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

1. Tsai, YT. et al. (2000) Molecular and cellular biology 20, 2043-54. PMID: 10688651

2. Yamamoto, T. et al. (2002) Biochemical and biophysical research communications 297, 811-7. PMID: 12359225

3. Shao, H. et al. (2003) Cancer research 63, 3923-30. PMID: 12873986

4. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 15194700

5. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507

6. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

7. Saxena, NK. et al. (2007) The Journal of biological chemistry 282, 13316-25. PMID: 17344214

8. Jiang, H. et al. (2008) Biochemical and biophysical research communications 368, 1-5. PMID: 18242580

9. Hou, T. et al. (2008) The Journal of biological chemistry 283, 30725-34. PMID: 18782771

10. Gao, X. et al. (2012) Molecular cell 45, 598-609. PMID: 22306293

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-STAT3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: A549 cell lysate
Lane 3: A431 cell lysate
Lane 4: 293T cell lysate