Anti-STAT4 Polyclonal Antibody (HC549014)

Name: Anti-STAT4 Polyclonal Antibody
Brand: abinScience
SKU: HC549014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC549014

Descripción

Anti-STAT4 Polyclonal Antibody (HC549014) is a rabbit polyclonal antibody detecting STAT4 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human STAT4 (Tyr505-Ile737).

Objetivo

Signal transducer and activator of transcription 4, STAT4

Purificación

Purified by antigen affinity column.

Número de acceso

Q14765

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Signal transducer and activator of transcription 4 (STAT4) is a ~85 kDa protein. Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response. Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma. Also participates in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps. After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated. Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes.

1. Visconti, R. et al. (2000) Blood 96, 1844-52. PMID: 10961885

2. Baghdassarian, H. et al. (2023) The New England journal of medicine 388, 2241-2252. PMID: 37256972

3. Cho, SS. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 157, 4781-9. PMID: 8943379

4. Morinobu, A. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 12281-6. PMID: 12213961

5. Zhang, YS. et al. (2022) Cell death and differentiation 29, 2303-2315. PMID: 35614130

6. Yao, BB. et al. (1999) Archives of biochemistry and biophysics 368, 147-55. PMID: 10415122

7. Bacon, CM. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7307-11. PMID: 7638186

8. Oppmann, B. et al. (2000) Immunity 13, 715-25. PMID: 11114383

9. Li, M. et al. (2021) Experimental cell research 407, 112784. PMID: 34508746

10. Gonzales-van Horn, SR. et al. (2016) European journal of immunology 46, 1504-10. PMID: 26990433

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-STAT4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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