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| カタログ番号 | JN936014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Streptococcus pyogenes EndoS Polyclonal Antibody (JN936014) is a rabbit polyclonal antibody detecting Streptococcus pyogenes EndoS in ELISA, IHC, WB.
Highlights
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| 種反応性 | Streptococcus pyogenes | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Streptococcus pyogenes EndoS (Glu37-Lys995). | ||||||||
| ターゲット | Endo-beta-N-acetylglucosaminidase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99Y92 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Endo-beta-N-acetylglucosaminidase EndoS (Endo S) is a ~111 kDa protein. Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection. Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway. Shows a specificity for biantennary complex type N-glycans; does neither cleave larger complex type glycans nor oligomannose and nor hybrid-type glycans. Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu. 1. Collin, M. et al. (2001) The EMBO journal 20, 3046-55. PMID: 11406581 2. Collin, M. et al. (2001) Infection and immunity 69, 7187-9. PMID: 11598100 3. Collin, M. et al. (2002) Infection and immunity 70, 6646-51. PMID: 12438337 4. Allhorn, M. et al. (2008) BMC microbiology 8, 3. PMID: 18182097 5. Allhorn, M. et al. (2010) Blood 115, 5080-8. PMID: 20357243 6. Sjögren, J. et al. (2011) BMC microbiology 11, 120. PMID: 21619648 7. Goodfellow, JJ. et al. (2012) Journal of the American Chemical Society 134, 8030-3. PMID: 22551167 8. Huang, W. et al. (2012) Journal of the American Chemical Society 134, 12308-18. PMID: 22747414 9. Dixon, EV. et al. (2014) The Journal of biological chemistry 289, 13876-89. PMID: 24668806 10. Trastoy, B. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 6714-9. PMID: 24753590 | ||||||||
| 注意事項 | For research use only. |
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