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| カタログ番号 | HX919014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SUMO2 Polyclonal Antibody (HX919014) is a rabbit polyclonal antibody detecting SUMO2 in ELISA, IHC, WB. Suitable for Bovine, Cricetulus griseus, Danio rerio, Chicken, and Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SUMO2 (Met1-Tyr95). | ||||||||
| ターゲット | Ubiquitin-like protein SMT3B, SMT3B, SUMO-3, Smt3B, Sentrin-2, SMT3 homolog 2, SMT3H2, SUMO2, HSMT3, Small ubiquitin-related modifier 2, SUMO-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P61956 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Small ubiquitin-related modifier 2 (SUMO2) is a ~10 kDa protein. Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX. 1. Cappadocia, L. et al. (2015) Nature structural & molecular biology 22, 968-75. PMID: 26524494 2. Tatham, MH. et al. (2008) Nature cell biology 10, 538-46. PMID: 18408734 3. Meulmeester, E. et al. (2008) Molecular cell 30, 610-9. PMID: 18538659 4. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678 5. Kamitani, T. et al. (1998) The Journal of biological chemistry 273, 11349-53. PMID: 9556629 6. Richard, P. et al. (2013) Genes & development 27, 2227-32. PMID: 24105744 | ||||||||
| 注意事項 | For research use only. |
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