Anti-SUV39H1 Polyclonal Antibody (HT471014)

Name: Anti-SUV39H1 Polyclonal Antibody
Brand: abinScience
SKU: HT471014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HT471014

Description

Anti-SUV39H1 Polyclonal Antibody (HT471014) is a rabbit polyclonal antibody detecting SUV39H1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SUV39H1 (Gly7-Met271).

Cible

Position-effect variegation 3-9 homolog, SUV39H, H3-K9-HMTase 1, SUV39H1, Histone-lysine N-methyltransferase SUV39H1, Su(var)3-9 homolog 1, Lysine N-methyltransferase 1A, Histone H3-K9 methyltransferase 1, Suppressor of variegation 3-9 homolog 1, KMT1A

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

O43463

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Histone-lysine N-methyltransferase SUV39H1 is a ~47 kDa protein. Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.

1. Rea, S. et al. (2000) Nature 406, 593-9. PMID: 10949293

2. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053

3. Vaquero, A. et al. (2007) Nature 450, 440-4. PMID: 18004385

4. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427

5. Nielsen, SJ. et al. (2001) Nature 412, 561-5. PMID: 11484059

6. Ait-Si-Ali, S. et al. (2004) The EMBO journal 23, 605-15. PMID: 14765126

Note

For research use only.

Images

Reférences

Fiche technique

Anti-SUV39H1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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