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| カタログ番号 | HT471014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SUV39H1 Polyclonal Antibody (HT471014) is a rabbit polyclonal antibody detecting SUV39H1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SUV39H1 (Gly7-Met271). | ||||||||
| ターゲット | Position-effect variegation 3-9 homolog, SUV39H, H3-K9-HMTase 1, SUV39H1, Histone-lysine N-methyltransferase SUV39H1, Su(var)3-9 homolog 1, Lysine N-methyltransferase 1A, Histone H3-K9 methyltransferase 1, Suppressor of variegation 3-9 homolog 1, KMT1A | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43463 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Histone-lysine N-methyltransferase SUV39H1 is a ~47 kDa protein. Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. 1. Rea, S. et al. (2000) Nature 406, 593-9. PMID: 10949293 2. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053 3. Vaquero, A. et al. (2007) Nature 450, 440-4. PMID: 18004385 4. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427 5. Nielsen, SJ. et al. (2001) Nature 412, 561-5. PMID: 11484059 6. Ait-Si-Ali, S. et al. (2004) The EMBO journal 23, 605-15. PMID: 14765126 | ||||||||
| 注意事項 | For research use only. |
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