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| カタログ番号 | HV760014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SYNE2 Polyclonal Antibody (HV760014) is a rabbit polyclonal antibody detecting SYNE2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SYNE2 (Glu6-Asp263). | ||||||||
| ターゲット | Nuclear envelope spectrin repeat protein 2, KIAA1011, Protein NUANCE, KASH domain-containing protein 2, Nesprin-2, Syne-2, NUA, SYNE2, Synaptic nuclear envelope protein 2, Nucleus and actin connecting element protein, KASH2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8WXH0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nesprin-2 (SYNE2) is a ~796 kDa protein. Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. 1. Wallis, SS. et al. (2021) Developmental cell 56, 3192-3202.e8. PMID: 34818527 | ||||||||
| 注意事項 | For research use only. |
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