Anti-TAB1 Polyclonal Antibody (HS933014)

Name: Anti-TAB1 Polyclonal Antibody
Brand: abinScience
SKU: HS933014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HS933014

Description

Anti-TAB1 Polyclonal Antibody (HS933014) is a rabbit polyclonal antibody detecting TAB1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human TAB1 (Leu189-Pro439).

Cible

MAP3K7IP1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q15750

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a ~54 kDa protein. Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits.

1. Pathak, S. et al. (2012) The EMBO journal 31, 1394-404. PMID: 22307082

2. Yang, CY. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 1547-57. PMID: 24403530

3. Sakurai, H. et al. (2000) FEBS letters 474, 141-5. PMID: 10838074

4. Charlaftis, N. et al. (2014) The EMBO journal 33, 2581-96. PMID: 25260751

5. Ma, M. et al. (2023) Molecular cell 83, 3885-3903.e5. PMID: 37832545

6. Ge, B. et al. (2002) Science (New York, N.Y.) 295, 1291-4. PMID: 11847341

7. Thapa, D. et al. (2018) Molecular and cellular biology 38. PMID: 29229647

8. Cheung, PC. et al. (2003) The EMBO journal 22, 5793-805. PMID: 14592977

9. Mendoza, H. et al. (2008) The Biochemical journal 409, 711-22. PMID: 18021073

Note

For research use only.

Images

Reférences

Fiche technique

Anti-TAB1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-TAB1 Polyclonal Antibody (HS933014)

Aperçu

Images

Reférences

Fiche technique

SDS