中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HS933014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TAB1 Polyclonal Antibody (HS933014) is a rabbit polyclonal antibody detecting TAB1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TAB1 (Leu189-Pro439). | ||||||||
| ターゲット | MAP3K7IP1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15750 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a ~54 kDa protein. Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits. 1. Pathak, S. et al. (2012) The EMBO journal 31, 1394-404. PMID: 22307082 2. Yang, CY. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 1547-57. PMID: 24403530 3. Sakurai, H. et al. (2000) FEBS letters 474, 141-5. PMID: 10838074 4. Charlaftis, N. et al. (2014) The EMBO journal 33, 2581-96. PMID: 25260751 5. Ma, M. et al. (2023) Molecular cell 83, 3885-3903.e5. PMID: 37832545 6. Ge, B. et al. (2002) Science (New York, N.Y.) 295, 1291-4. PMID: 11847341 7. Thapa, D. et al. (2018) Molecular and cellular biology 38. PMID: 29229647 8. Cheung, PC. et al. (2003) The EMBO journal 22, 5793-805. PMID: 14592977 9. Mendoza, H. et al. (2008) The Biochemical journal 409, 711-22. PMID: 18021073 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
