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| カタログ番号 | HV178014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TBK1 Polyclonal Antibody (HV178014) is a rabbit polyclonal antibody detecting TBK1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TBK1 (Met1-Gly121). | ||||||||
| ターゲット | Serine/threonine-protein kinase TBK1, NAK, TANK-binding kinase 1, T2K, TBK1, NF-kappa-B-activating kinase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UHD2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein kinase TBK1 is a ~83 kDa protein. Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1. 1. Pomerantz, JL. et al. (1999) The EMBO journal 18, 6694-704. PMID: 10581243 2. Kishore, N. et al. (2002) The Journal of biological chemistry 277, 13840-7. PMID: 11839743 3. Fitzgerald, KA. et al. (2003) Nature immunology 4, 491-6. PMID: 12692549 4. Sharma, S. et al. (2003) Science (New York, N.Y.) 300, 1148-51. PMID: 12702806 5. Mori, M. et al. (2004) The Journal of biological chemistry 279, 9698-702. PMID: 14703513 6. tenOever, BR. et al. (2004) Journal of virology 78, 10636-49. PMID: 15367631 7. Kuai, J. et al. (2004) The Journal of biological chemistry 279, 53266-71. PMID: 15485837 8. Soulat, D. et al. (2008) The EMBO journal 27, 2135-46. PMID: 18583960 9. Clark, K. et al. (2011) The Biochemical journal 434, 93-104. PMID: 21138416 10. Larabi, A. et al. (2013) Cell reports 3, 734-46. PMID: 23453971 | ||||||||
| 注意事項 | For research use only. |
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