Anti-TBK1 Polyclonal Antibody (HV178014)

Name: Anti-TBK1 Polyclonal Antibody
Brand: abinScience
SKU: HV178014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HV178014

Описание

Anti-TBK1 Polyclonal Antibody (HV178014) is a rabbit polyclonal antibody detecting TBK1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human TBK1 (Met1-Gly121).

Цель

Serine/threonine-protein kinase TBK1, NAK, TANK-binding kinase 1, T2K, TBK1, NF-kappa-B-activating kinase

Очистка

Purified by antigen affinity column.

Номер доступа

Q9UHD2

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Serine/threonine-protein kinase TBK1 is a ~83 kDa protein. Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1.

1. Pomerantz, JL. et al. (1999) The EMBO journal 18, 6694-704. PMID: 10581243

2. Kishore, N. et al. (2002) The Journal of biological chemistry 277, 13840-7. PMID: 11839743

3. Fitzgerald, KA. et al. (2003) Nature immunology 4, 491-6. PMID: 12692549

4. Sharma, S. et al. (2003) Science (New York, N.Y.) 300, 1148-51. PMID: 12702806

5. Mori, M. et al. (2004) The Journal of biological chemistry 279, 9698-702. PMID: 14703513

6. tenOever, BR. et al. (2004) Journal of virology 78, 10636-49. PMID: 15367631

7. Kuai, J. et al. (2004) The Journal of biological chemistry 279, 53266-71. PMID: 15485837

8. Soulat, D. et al. (2008) The EMBO journal 27, 2135-46. PMID: 18583960

9. Clark, K. et al. (2011) The Biochemical journal 434, 93-104. PMID: 21138416

10. Larabi, A. et al. (2013) Cell reports 3, 734-46. PMID: 23453971

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-TBK1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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