

| Numéro de catalogue | HW608024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-TCF7 Polyclonal Antibody (HW608024) is a rabbit polyclonal antibody detecting Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1 in ELISA, IHC, WB. Suitable for Mouse, Human, Zebrafish, Frog, and Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant human TCF7 (Lys270-Glu355). | ||||||||
| Cible | Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q00417, P36402, Q9NQB0, Q924A0, Q9YHE8, P70063, P70062, Q90ZB6, Q800Q5, P70064, P27782, Q9QXN1, Q9UJU2, Q9HCS4, Q9Z1J1, Q8IMA8, P91943 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Transcription factor 7 (TCF7) is a ~45 kDa protein. Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. 1. Melichar, HJ. et al. (2007) Science (New York, N.Y.) 315, 230-3. PMID: 17218525 2. Malhotra, N. et al. (2013) Immunity 38, 681-93. PMID: 23562159 3. Spidale, NA. et al. (2018) Immunity 49, 857-872.e5. PMID: 30413363 | ||||||||
| Note | For research use only |
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