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Anti-TCF7 Polyclonal Antibody (HW608024)

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Aperçu
Numéro de catalogueHW608024
Description
Anti-TCF7 Polyclonal Antibody (HW608024) is a rabbit polyclonal antibody detecting Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1 in ELISA, IHC, WB. Suitable for Mouse, Human, Zebrafish, Frog, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant human TCF7 (Lys270-Glu355).
Cible Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès Q00417, P36402, Q9NQB0, Q924A0, Q9YHE8, P70063, P70062, Q90ZB6, Q800Q5, P70064, P27782, Q9QXN1, Q9UJU2, Q9HCS4, Q9Z1J1, Q8IMA8, P91943
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Transcription factor 7 (TCF7) is a ~45 kDa protein. Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages.

1. Melichar, HJ. et al. (2007) Science (New York, N.Y.) 315, 230-3. PMID: 17218525
2. Malhotra, N. et al. (2013) Immunity 38, 681-93. PMID: 23562159
3. Spidale, NA. et al. (2018) Immunity 49, 857-872.e5. PMID: 30413363
Note For research use only
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Formula
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