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Anti-TCF7 Polyclonal Antibody (HW608024)

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概要
カタログ番号HW608024
説明
Anti-TCF7 Polyclonal Antibody (HW608024) is a rabbit polyclonal antibody detecting Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1 in ELISA, IHC, WB. Suitable for Mouse, Human, Zebrafish, Frog, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
種反応性Human, Mouse, Rat
アプリケーションELISA, IHC, WB
宿主種Rabbit
クローン性Polyclonal
アイソタイプIgG
免疫原 E. coli - derived recombinant human TCF7 (Lys270-Glu355).
ターゲット Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1
エンドトキシンレベル Please contact with the lab for this information.
精製 Purified by antigen affinity column.
アクセッション番号 Q00417, P36402, Q9NQB0, Q924A0, Q9YHE8, P70063, P70062, Q90ZB6, Q800Q5, P70064, P27782, Q9QXN1, Q9UJU2, Q9HCS4, Q9Z1J1, Q8IMA8, P91943
形態 Liquid
保存バッファー 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報
アプリケーション 希釈
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
安定性と保存 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Transcription factor 7 (TCF7) is a ~45 kDa protein. Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages.

1. Melichar, HJ. et al. (2007) Science (New York, N.Y.) 315, 230-3. PMID: 17218525
2. Malhotra, N. et al. (2013) Immunity 38, 681-93. PMID: 23562159
3. Spidale, NA. et al. (2018) Immunity 49, 857-872.e5. PMID: 30413363
注意事項 For research use only
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参考文献
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