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| カタログ番号 | HA813014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TESK1 Polyclonal Antibody (HA813014) is a rabbit polyclonal antibody detecting Dual specificity testis-specific protein kinase 1; 2.7.12.1; Testicular protein kinase 1; TESK1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human TESK1 (Ser39-Leu318). | ||||||||
| ターゲット | Dual specificity testis-specific protein kinase 1; 2.7.12.1; Testicular protein kinase 1; TESK1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15569, O70146, Q63572 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dual specificity testis-specific protein kinase 1 (TESK1) is a ~67 kDa protein. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. 1. Tsumura, Y. et al. (2005) The Biochemical journal 387, 627-37. PMID: 15584898 2. Kim, J. et al. (2015) Nature communications 6, 6781. PMID: 25849865 | ||||||||
| 注意事項 | For research use only |
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