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Anti-TGFBR3 Polyclonal Antibody (HA790014)

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Anti-TGFBR3 Polyclonal Antibody
Anti-TGFBR3 Polyclonal Antibody
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Vista general
Número de catálogoHA790014
Descripción
Anti-TGFBR3 Polyclonal Antibody (HA790014) is a rabbit polyclonal antibody detecting Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III; TGFBR3 in ELISA, IHC, WB. Suitable for Human, Pig, Rat, and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human TGFBR3 (Ser36-Glu360).
Objetivo Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III; TGFBR3
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q03167, P35054, P26342, O88393
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Transforming growth factor beta receptor type 3 (TGFBR3) is a ~93 kDa protein. Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B.

1. Chen, W. et al. (2003) Science (New York, N.Y.) 301, 1394-7. PMID: 12958365
2. Mythreye, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 8221-6. PMID: 19416857
3. Kirkbride, KC. et al. (2008) The Journal of biological chemistry 283, 7628-37. PMID: 18184661
4. Lee, NY. et al. (2009) Molecular biology of the cell 20, 4362-70. PMID: 19726563
5. Mythreye, K. et al. (2013) Oncogene 32, 1416-27. PMID: 22562249
6. You, HJ. et al. (2009) Carcinogenesis 30, 1281-7. PMID: 19325136
Nota For research use only
Imágenes
  • Anti-TGFBR3 Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-TGFBR3 polyclonal antibody at 1ug/mL on various samples.
    Lane 1: NIH3T3 cell lysate
    Lane 2: PC-12 cell lysate

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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