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Anti-TH Polyclonal Antibody (HY108014)

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Vista general
Número de catálogoHY108014
Descripción
Anti-TH Polyclonal Antibody (HY108014) is a rabbit polyclonal antibody detecting TH in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human TH (Met1-Ile260).
Objetivo Tyrosine 3-hydroxylase, TYH, Tyrosine 3-monooxygenase, TH
Purificación Purified by antigen affinity column.
Número de acceso P07101
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Tyrosine 3-monooxygenase (TH) is a ~58 kDa protein. Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development.

1. Sura, GR. et al. (2004) Journal of neurochemistry 90, 970-8. PMID: 15287903
2. Le Bourdellès, B. et al. (1991) The Journal of biological chemistry 266, 17124-30. PMID: 1680128
3. Roma, J. et al. (2007) Biological chemistry 388, 419-26. PMID: 17391063
4. Fossbakk, A. et al. (2014) Human mutation 35, 880-90. PMID: 24753243
5. Inukai, S. et al. (2022) Biochemical and biophysical research communications 589, 209-214. PMID: 34922205
6. Knappskog, PM. et al. (1995) Human molecular genetics 4, 1209-12. PMID: 8528210
Nota For research use only.
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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