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| カタログ番号 | HY108014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TH Polyclonal Antibody (HY108014) is a rabbit polyclonal antibody detecting TH in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TH (Met1-Ile260). | ||||||||
| ターゲット | Tyrosine 3-hydroxylase, TYH, Tyrosine 3-monooxygenase, TH | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07101 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tyrosine 3-monooxygenase (TH) is a ~58 kDa protein. Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development. 1. Sura, GR. et al. (2004) Journal of neurochemistry 90, 970-8. PMID: 15287903 2. Le Bourdellès, B. et al. (1991) The Journal of biological chemistry 266, 17124-30. PMID: 1680128 3. Roma, J. et al. (2007) Biological chemistry 388, 419-26. PMID: 17391063 4. Fossbakk, A. et al. (2014) Human mutation 35, 880-90. PMID: 24753243 5. Inukai, S. et al. (2022) Biochemical and biophysical research communications 589, 209-214. PMID: 34922205 6. Knappskog, PM. et al. (1995) Human molecular genetics 4, 1209-12. PMID: 8528210 | ||||||||
| 注意事項 | For research use only. |
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